1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene

Base Information

• Chemical Name: 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene
• CAS No.: 93273-58-6
• Molecular Formula: C₂₂H₂₇NO
• Molecular Weight: 321.462
• Mol file: 93273-58-6.mol

Synonyms:

Chemical Property of 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene

There total 8 articles about 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

β-(m-methoxyphenyl)-α-phenylpropionic acid (93300-81-3) → 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene (93273-58-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 95 percent / H₂SO₄ / 12 h / Heating

2: 66 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

3: 70 percent / pyridine / 12 h / Ambient temperature

4: 76 percent / dimethylformamide / 12 h / Ambient temperature

5: 79 percent / 2N NaOH / ethane-1,2-diol / 18 h / Heating

6: PCl₅ / benzene / 1 h / Heating

7: SnCl₄ / benzene / 6 h / Ambient temperature

8: 1.) Mg / 1.) Et₂O, 4h reflux 2.) 20h reflux

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; phosphorus pentachloride; sulfuric acid; tin(IV) chloride; magnesium; In diethyl ether; ethylene glycol; N,N-dimethyl-formamide; benzene;

Reference yield:

3-(m-methoxyphenyl)-2-phenylpropan-1-ol (93273-51-9) → 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene (93273-58-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent / pyridine / 12 h / Ambient temperature

2: 76 percent / dimethylformamide / 12 h / Ambient temperature

3: 79 percent / 2N NaOH / ethane-1,2-diol / 18 h / Heating

4: PCl₅ / benzene / 1 h / Heating

5: SnCl₄ / benzene / 6 h / Ambient temperature

6: 1.) Mg / 1.) Et₂O, 4h reflux 2.) 20h reflux

With pyridine; sodium hydroxide; phosphorus pentachloride; tin(IV) chloride; magnesium; In ethylene glycol; N,N-dimethyl-formamide; benzene;

Reference yield:

4-(m-methoxyphenyl)-3-phenylbutyronitrile (93273-53-1) → 1-(3-dimethylaminopropyl)-3-phenyl-6-methoxy-3,4-dihydronaphthalene (93273-58-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 79 percent / 2N NaOH / ethane-1,2-diol / 18 h / Heating

2: PCl₅ / benzene / 1 h / Heating

3: SnCl₄ / benzene / 6 h / Ambient temperature

4: 1.) Mg / 1.) Et₂O, 4h reflux 2.) 20h reflux

With sodium hydroxide; phosphorus pentachloride; tin(IV) chloride; magnesium; In ethylene glycol; benzene;

upstream raw materials:

6-methoxy-3-phenyl-1-tetralone

3-(Dimethylamino)propyl chloride

β-(m-methoxyphenyl)-α-phenylpropionic acid

3-(m-methoxyphenyl)-2-phenylpropan-1-ol