5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine

Base Information

Chemical Name:5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine
CAS No.:77720-36-6
Molecular Formula:C₁₈H₁₂N₄O₄
Molecular Weight:348.318
Hs Code.:
DSSTox Substance ID:DTXSID401192965

Synonyms:DTXSID401192965;5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine;77720-36-6

Suppliers and Price of 5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:348.08585488
Heavy Atom Count:26
Complexity:490

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(OC(=C2C3=CC=CC=C3)[N+](=O)[O-])C4=NN=C(O4)N

Technology Process of 5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine

There total 6 articles about 5-(5-Nitro-3,4-diphenyl-2-furanyl)-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 506-68-3
bromocyane

: 77719-88-1
5-nitro-3,4-diphenyl-2-furoylhydrazine

: 77720-36-6
2-amino-5-(5-nitro-3,4-diphenyl-2-furyl)-1,3,4-oxazole

Guidance literature:: In methanol; for 1.5h; Heating;
DOI:10.1248/cpb.29.635

Reference yield:

: 52101-36-7
methyl 3,4-diphenylfuran-2-carboxylate

: 77720-36-6
2-amino-5-(5-nitro-3,4-diphenyl-2-furyl)-1,3,4-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 20 percent / acetyl nitrate / 1.5 h / -30 °C

2: 92 percent / 2.5percent NaOH / dioxane / 0.5 h / Ambient temperature

3: 92 percent / SOCl₂ / 3 h / Heating

4: 60 percent / hydrazin hydrate / ethanol; benzene / 0.25 h / 0 - 3 °C

5: 75 percent / methanol / 1.5 h / Heating

With sodium hydroxide; thionyl chloride; nitro acetate; hydrazine hydrate; In 1,4-dioxane; methanol; ethanol; benzene;
DOI:10.1248/cpb.29.635

Reference yield:

: 52101-40-3
5-nitro-3,4-diphenylfuran-2-carboxylic acid

: 77720-36-6
2-amino-5-(5-nitro-3,4-diphenyl-2-furyl)-1,3,4-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / SOCl₂ / 3 h / Heating

2: 60 percent / hydrazin hydrate / ethanol; benzene / 0.25 h / 0 - 3 °C

3: 75 percent / methanol / 1.5 h / Heating

With thionyl chloride; hydrazine hydrate; In methanol; ethanol; benzene;
DOI:10.1248/cpb.29.635