2-AMINO-1-(2,5-DIMETHOXYPHENYL)-1-PROPANONE

Base Information

• Chemical Name: 2-AMINO-1-(2,5-DIMETHOXYPHENYL)-1-PROPANONE
• CAS No.: 103565-48-6
• Molecular Formula: C11H15NO3.ClH
• Molecular Weight: 245.706
• Mol file: 103565-48-6.mol

Synonyms:1-Propanone,2-amino-1-(2,5-dimethoxyphenyl)-,hydrochloride;2-amino-1-(2,5-dimethoxy-phenyl)-propan-1-one,hydrochloride;2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-on,Hydrochlorid;

Chemical Property of 2-AMINO-1-(2,5-DIMETHOXYPHENYL)-1-PROPANONE

Chemical Property:

• PSA: 61.55000
• LogP: 1.93400

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-1-(2,5-DIMETHOXYPHENYL)-1-PROPANONE

There total 3 articles about 2-AMINO-1-(2,5-DIMETHOXYPHENYL)-1-PROPANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.83%

1-(2,5-dimethoxyphenyl)-2-hydroxyimino-1-acetone (121347-31-7) → 2,5-dimethoxy-α-aminopropiophenone hydrochloride (103565-48-6)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; Reagent/catalyst;

Reference yield: 75.0%

(RS)-2-trifluoroacetamido-1-(2,5-dimethoxyphenyl)-1-propanone (742095-47-2) → 2,5-dimethoxy-α-aminopropiophenone hydrochloride (103565-48-6)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol;

DOI:10.1016/j.bmc.2004.05.033

Reference yield:

2',5'-dimethoxypropiophenone (5803-30-5) → 2,5-dimethoxy-α-aminopropiophenone hydrochloride (103565-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; n-Butyl nitrite / diethyl ether / 20 °C / Cooling with ice

2: hydrogen; hydrogenchloride; palladium 10% on activated carbon / methanol / 20 °C

With hydrogenchloride; n-Butyl nitrite; palladium 10% on activated carbon; hydrogen; In methanol; diethyl ether;

upstream raw materials:

(RS)-2-trifluoroacetamido-1-(2,5-dimethoxyphenyl)-1-propanone

2',5'-dimethoxypropiophenone

1-(2,5-dimethoxyphenyl)-2-hydroxyimino-1-acetone

Downstream raw materials:

2-amino-1-(2,5-dimethoxyphenyl)-1-propanol

Refernces

• 1、 Osorio-Olivares, Mauricio,Rezende, Marcos Caroli,Sepulveda-Boza, Silvia,Cassels, Bruce K.,Fierro, Angelica. "MAO inhibition by arylisopropylamines: The effect of oxygen substituents at the β-position". . p. 4055 - 4066. Retrieved 2007/10/03.