methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate

Base Information

• Chemical Name: methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate
• CAS No.: 82343-33-7
• Molecular Formula: C₁₇H₁₆O₂
• Molecular Weight: 252.313
• Mol file: 82343-33-7.mol

Synonyms:

Chemical Property of methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate

There total 4 articles about methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-Diphenylethylene (530-48-3) → methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate (82343-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 Angsroem molecular sieves / (R,R)-diphenylethylenediamine, cyclobutanone; Cu(OTf)2*C₆H₆ / CH₂Cl₂ / 24 h / 20 °C

2: NaOH (aq)

With sodium hydroxide; 4 A molecular sieve; cyclobutanone; (R,R)-1,2-diphenylethylenediamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane;

DOI:10.1016/j.tetlet.2003.12.061

Reference yield:

1,1-Diphenylethylene (530-48-3) + methyl diazoacetate (6832-16-2) → methyl-2,2-diphenyl-cyclopropane carboxylate (25140-26-5) + methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate (82343-33-7)

Guidance literature:

With 4-[((S)-4-tBu-4H,5H-2-oxazolyl)2-NCH₂]-C₆H₄-CH₂-PEG-OMe; phenylhydrazine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; for 8h; Further Variations:; Reagents; Product distribution;

DOI:10.1002/adsc.200505197

Reference yield:

methyl 2,2-diphenylcyclopropane-1-carboxylate (19179-60-3) → methyl-2,2-diphenyl-cyclopropane carboxylate (25140-26-5) + methyl (S)-(+)-2,2-diphenylcyclopropanecarboxylate (82343-33-7)

Guidance literature:

With hydrogenchloride; chiral LiN(CH(CH₃)Ph)2; In tetrahydrofuran; Product distribution; Multistep reaction; the chemical and optical yield of the product was investigated;

DOI:10.1016/S0040-4039(00)84059-9

upstream raw materials:

methyl 2,2-diphenylcyclopropane-1-carboxylate

1,1-Diphenylethylene

methyl diazoacetate

diazomethane