Acetamide, N-[2-(4-morpholinyl)-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]-

Base Information

• Chemical Name: Acetamide, N-[2-(4-morpholinyl)-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]-
• CAS No.: 103585-24-6
• Molecular Formula: C17H22N4O3
• Molecular Weight: 330.387
• Mol file: 103585-24-6.mol

Synonyms:

Chemical Property of Acetamide, N-[2-(4-morpholinyl)-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-[2-(4-morpholinyl)-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]-

There total 8 articles about Acetamide, N-[2-(4-morpholinyl)-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

acetic anhydride (108-24-7) + 6-(3-amino-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one (103585-23-5) → 6-(3-acetamido-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one (103585-24-6)

Guidance literature:

With diisopropylamine; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1016/0223-5234(91)90121-3

Reference yield:

α-morpholino-α-(4-morpholino-3-nitro-phenyl)-acetonitrile (139080-77-6) → 6-(3-acetamido-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one (103585-24-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) methanolic KOH / 1.) THF, 25 deg C, 10 min, 2.) THF, RT, 5 h

2: 97 percent / glacial AcOH / H₂O / 18 h / Heating

3: 57 percent / conc HCl / H₂O / 1.5 h / 100 °C

4: 77 percent / H₂NNH₂*H₂O / ethanol / 4 h / Heating

5: 75 percent / H₂ / 5percent Pd/C / dimethylformamide / 2280 Torr / Ambient temperature

6: 67 percent / iPr₂NH / dimethylformamide / 48 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; hydrogen; hydrazine hydrate; acetic acid; diisopropylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(91)90121-3

Reference yield:

4-(4-morpholino-3-nitrophenyl)-4-oxo-3-methylbutyronitrile (103585-31-5) → 6-(3-acetamido-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one (103585-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / conc HCl / H₂O / 1.5 h / 100 °C

2: 77 percent / H₂NNH₂*H₂O / ethanol / 4 h / Heating

3: 75 percent / H₂ / 5percent Pd/C / dimethylformamide / 2280 Torr / Ambient temperature

4: 67 percent / iPr₂NH / dimethylformamide / 48 h / Ambient temperature

With hydrogenchloride; hydrogen; hydrazine hydrate; diisopropylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(91)90121-3

upstream raw materials:

acetic anhydride

6-(3-amino-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one

α-morpholino-α-(4-morpholino-3-nitro-phenyl)-acetonitrile

4-(4-morpholino-3-nitrophenyl)-4-oxo-3-methylbutyronitrile