Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester
• CAS No.: 1026341-63-8
• Molecular Formula: C₃₁H₂₆N₄O₆S
• Molecular Weight: 582.637

Synonyms:

Chemical Property of Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester

Chemical Property:

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Useful:

Technology Process of Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester

There total 6 articles about Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>aniline (103788-87-0) → Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester (1026341-63-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / CHCl₃ / Ambient temperature

2: 4-(dimethylamino)pyridine, pyridine / xylene / 25 h / Heating

3: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

4: acetic anhydride / 0.83 h / Heating

5: dimethylsulfoxide / 1.42 h / Ambient temperature

With pyridine; dmap; potassium tert-butylate; acetic anhydride; In chloroform; dimethyl sulfoxide; xylene;

DOI:10.1021/jm00102a016

Reference yield:

2-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (1027092-56-3) → Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester (1026341-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

2: acetic anhydride / 0.83 h / Heating

3: dimethylsulfoxide / 1.42 h / Ambient temperature

With potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide;

DOI:10.1021/jm00102a016

Reference yield:

2-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenylsulfamoyl}-benzoic acid methyl ester → Cyano-(3-cyano-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-acetic acid ethyl ester (1026341-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 4-(dimethylamino)pyridine, pyridine / xylene / 25 h / Heating

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: acetic anhydride / 0.83 h / Heating

4: dimethylsulfoxide / 1.42 h / Ambient temperature

With pyridine; dmap; potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; xylene;

DOI:10.1021/jm00102a016

upstream raw materials:

potassium cyanide

4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>aniline

2-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

2-Cyano-3-(2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenylsulfamoyl}-phenyl)-3-oxo-propionic acid ethyl ester

Downstream raw materials:

C₃₀H₂₅N₃O₈S

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