6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester

Base Information

• Chemical Name: 6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester
• CAS No.: 669693-36-1
• Molecular Formula: C₂₁H₂₅F₅N₄O₇
• Molecular Weight: 540.444
• Mol file: 669693-36-1.mol

Synonyms:

Chemical Property of 6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester

There total 2 articles about 6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-aminocaproate hydrochloride (1926-80-3) → 6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester (669693-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 96 percent / diisopropylethylamine

2.1: aq. sodium hydroxide / dioxane

2.2: Amberlite IR-120 H+

3.1: 64 percent / EDCI / dioxane

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2003.10.105

Reference yield:

6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid methyl ester (669693-35-0) → 6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid pentafluorophenyl ester (669693-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. sodium hydroxide / dioxane

1.2: Amberlite IR-120 H+

2.1: 64 percent / EDCI / dioxane

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2003.10.105

upstream raw materials:

methyl 6-aminocaproate hydrochloride

6-{[(4S,5S)-5-((1R,2R)-3-Azido-1,2-dihydroxy-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-amino}-hexanoic acid methyl ester