5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one

Base Information

Chemical Name:5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one
CAS No.:103619-93-8
Molecular Formula:C21H20O2
Molecular Weight:304.389
Hs Code.:
DSSTox Substance ID:DTXSID90546821
Wikidata:Q82424739
Mol file:103619-93-8.mol

Synonyms:103619-93-8;5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one;DTXSID90546821

Suppliers and Price of 5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one

Chemical Property:

XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:304.146329876
Heavy Atom Count:23
Complexity:486

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=CC(=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O1

Technology Process of 5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one

There total 3 articles about 5-tert-Butyl-3-(diphenylmethylidene)furan-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: C₂₂H₂₄O₃

: C₂₂H₂₄O₃

: 103619-93-8
5-tert-butyl-3-(diphenylmethylene)-2(3H)-furanone

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at 0 - 20 ℃; Schlenk technique; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.orglett.0c03976

Reference yield:

: 119-61-9
benzophenone

: 77903-42-5
2-tert-Butyl-2-trimethylsilanyloxy-cyclopropanecarboxylic acid methyl ester

: 103619-93-8
5-tert-butyl-3-(diphenylmethylene)-2(3H)-furanone

Guidance literature:: With methanesulfonic acid; phosphorus pentoxide; titanium tetrachloride; Yield given. Multistep reaction; 1.) CH₂Cl₂; -78 deg C, 20 min; RT, 2h 2.) RT, 18h;

Reference yield:

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 538-44-3
4,4-dimethyl-1-phenyl-1-penten-3-one

: C₂₂H₂₄O₃

: 103619-93-8
5-tert-butyl-3-(diphenylmethylene)-2(3H)-furanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dimethyl phosphite; lithium hexamethyldisilazane / dichloromethane / 0.17 h / -15 °C / Inert atmosphere

1.2: 2 h / -15 °C / Inert atmosphere

2.1: trifluorormethanesulfonic acid / dichloromethane / 0 - 20 °C / Schlenk technique; Sealed tube; Inert atmosphere

With trifluorormethanesulfonic acid; Dimethyl phosphite; lithium hexamethyldisilazane; In dichloromethane;
DOI:10.1021/acs.orglett.0c03976