Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

Base Information

Chemical Name:Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide
CAS No.:168473-54-9
Molecular Formula:C₃₃H₃₇F₄N₅O₄S
Molecular Weight:675.747
Hs Code.:

Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

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Chemical Property of Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

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Technology Process of Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

There total 6 articles about Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 168473-54-9
Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 50 deg C, 3 h

4: KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

5: SnCl₂, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

6: DMAP, pyridine / Ambient temperature

With pyridine; hydrogenchloride; dmap; potassium fluoride; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; tin(ll) chloride; potassium bromide; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004

Reference yield:

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 168473-54-9
Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 50 deg C, 3 h

4: KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

5: SnCl₂, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

6: DMAP, pyridine / Ambient temperature

With pyridine; hydrogenchloride; dmap; potassium fluoride; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; tin(ll) chloride; potassium bromide; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004

Reference yield:

: 159547-20-3
3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl

: 168473-54-9
Pentanoic acid {3-[4-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-3-ethyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / CCl₄ / Heating; Irradiation

2: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 50 deg C, 3 h

3: KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

4: SnCl₂, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

5: DMAP, pyridine / Ambient temperature

With pyridine; hydrogenchloride; dmap; potassium fluoride; copper(l) iodide; bromine; sodium hydride; tin(ll) chloride; potassium bromide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004