(3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester

Base Information

• Chemical Name: (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester
• CAS No.: 168038-85-5
• Molecular Formula: C₂₆H₃₇NO₂S
• Molecular Weight: 427.651
• Mol file: 168038-85-5.mol

Synonyms:

Chemical Property of (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester

There total 3 articles about (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S)-2-(N,N-Dibenzylamino)-3-methylpentanal (125655-07-4) + C28H53BOS → (3R,4S,5S)-4-Dibenzylamino-3-hydroxy-5-methyl-heptanethioic acid S-tert-butyl ester + (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester (168038-85-5)

Guidance literature:

With triethylamine; In diethyl ether; dichloromethane; Yield given. Yields of byproduct given;

DOI:10.1021/jo00125a002

Reference yield:

(2S,3S)-2-(N,N-Dibenzylamino)-3-methylpentanal (125655-07-4) + C28H53BOS → (3R,4S,5S)-4-Dibenzylamino-3-hydroxy-5-methyl-heptanethioic acid S-tert-butyl ester + (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester (168038-85-5)

Guidance literature:

With triethylamine; In diethyl ether; dichloromethane; Yield given. Yields of byproduct given;

DOI:10.1021/jo00125a002

Reference yield:

(2S,3S)-2-(N,N-Dibenzylamino)-3-methylpentanal (125655-07-4) + C28H53BOS → (3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester (168038-85-5) + (3R,4S,5S)-4-[N,N]-dibenzylamino-3-hydroxy-5-methylheptanoic acid tert-butyl thioester

Guidance literature:

With dihydrogen peroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) ethyl ether, dichloromethane, -78 deg C, 18 h, 2.) MeOH, room temperature, 45 min;

DOI:10.1016/S0040-4020(97)00215-9

upstream raw materials:

(2S,3S)-2-(N,N-Dibenzylamino)-3-methylpentanal

Downstream raw materials:

(3S,4S,5S)-4--dibenzylamino-3-hydroxy-5-methylheptanoic acid methyl ester

(3S,4S,5S)-4-Dibenzylamino-3-hydroxy-5-methyl-heptanoic acid