2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester
CAS No.:187971-24-0
Molecular Formula:C₃₂H₃₃ClN₂O₇Si
Molecular Weight:621.162
Hs Code.:

2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

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Chemical Property of 2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

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Technology Process of 2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

There total 1 articles about 2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 609-65-4
o-chlorobenzoyl chloride

: 130351-68-7
1-(5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)uracil

: 187971-24-0
2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

Guidance literature:: In pyridine; dichloromethane; at -78 ℃; for 1h; Yield given;
DOI:10.1021/jo962080o

Reference yield:

: 187971-24-0
2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

: 187971-27-3
2-Chloro-benzoic acid (2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxymethoxy]-5-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride, acetic acid / 24 h / Ambient temperature

2: 55 percent / NIS, TfOH

3: 84 percent / tetrabutylammonum fluoride / acetonitrile / 3 h / Ambient temperature

With N-iodo-succinimide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; acetic anhydride; acetic acid; In acetonitrile;
DOI:10.1021/jo962080o

Reference yield:

: 187971-24-0
2-Chloro-benzoic acid (2R,3R,4R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

: 187971-28-4
C₄₆H₄₃ClN₄O₁₄

Guidance literature:: Multi-step reaction with 4 steps

1: acetic anhydride, acetic acid / 24 h / Ambient temperature

2: 55 percent / NIS, TfOH

3: 84 percent / tetrabutylammonum fluoride / acetonitrile / 3 h / Ambient temperature

4: 65 percent

With N-iodo-succinimide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; acetic anhydride; acetic acid; In acetonitrile;
DOI:10.1021/jo962080o