(S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester
CAS No.:213688-60-9
Molecular Formula:C₃₂H₅₀N₄O₈
Molecular Weight:618.771
Hs Code.:

(S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

There total 1 articles about (S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82362-19-4
Gly-Phe-Leu(t-Bu)

: (1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarboxylic acid

: 213688-60-9
(S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Yield given; Ambient temperature;
DOI:10.1016/S0960-894X(98)00349-7

Reference yield:

: 213688-60-9
(S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

: (S)-2-{(S)-2-[2-({(1R,2S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2-hydroxy-cyclopentanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 4-dimethylamino-pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) TFA, 2.) 10percent aq. (NH₄)HCO₃ / 1.) CH₂Cl₂, 0 deg C, 1 h

With dmap; ammonium bicarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00349-7

Reference yield:

: 47375-34-8
Boc-Tyr(t-Bu)-OH

: 213688-60-9
(S)-2-((S)-2-{2-[((1R,2S)-1-tert-Butoxycarbonylamino-2-hydroxy-cyclopentanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

: 213688-85-8
(S)-2-{(S)-2-[2-({(1R,2S)-1-tert-Butoxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionyloxy]-cyclopentanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h; Yield given; Ambient temperature;
DOI:10.1016/S0960-894X(98)00349-7