21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane

Base Information

• Chemical Name: 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane
• CAS No.: 53508-42-2
• Molecular Formula: C₃₃H₄₇NO₉S
• Molecular Weight: 633.803
• Mol file: 53508-42-2.mol

Synonyms:

Chemical Property of 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane

There total 4 articles about 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-17-nor-atidan-15β-ol (53580-01-1) → 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane (53508-42-2,53956-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃, Py / CH₂Cl₂

2: (i) NaBH₄, THF, aq. MeOH, (ii) /BRN= 607898/, Py

With pyridine; chromium(VI) oxide; In dichloromethane;

DOI:10.1021/ja00822a048

Reference yield:

21-acetyl-15β-benzoyloxy-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-17-nor-atidane (53508-40-0) → 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane (53508-42-2,53956-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: (alkaline hydrolysis)

2: CrO₃, Py / CH₂Cl₂

3: (i) NaBH₄, THF, aq. MeOH, (ii) /BRN= 607898/, Py

With pyridine; chromium(VI) oxide; In dichloromethane;

DOI:10.1021/ja00822a048

Reference yield:

21-acetyl-15β-benzoyloxy-1α,13β-dimethoxy-4-methoxymethyl-17-nor-atidan-16-one (53508-39-7) → 21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-15α-(toluene-4-sulfonyloxy)-17-nor-atidane (53508-42-2,53956-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: HC(OMe)3, H₂SO₄

2: (alkaline hydrolysis)

3: CrO₃, Py / CH₂Cl₂

4: (i) NaBH₄, THF, aq. MeOH, (ii) /BRN= 607898/, Py

With pyridine; chromium(VI) oxide; sulfuric acid; trimethyl orthoformate; In dichloromethane;

DOI:10.1021/ja00822a048

upstream raw materials:

21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-17-nor-atidan-15-one

p-toluenesulfonyl chloride

21-acetyl-16,16-ethane-1,2-diyldioxy-1α,13β-dimethoxy-4-methoxymethyl-17-nor-atidan-15β-ol

21-acetyl-15β-benzoyloxy-1α,13β-dimethoxy-4-methoxymethyl-17-nor-atidan-16-one