N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Base Information

• Chemical Name: N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide
• CAS No.: 198703-58-1
• Molecular Formula: C₃₇H₃₉N₅O₈
• Molecular Weight: 681.745
• Mol file: 198703-58-1.mol

Synonyms:

Chemical Property of N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

There total 5 articles about N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{9-[(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-methoxy-4-((E)-styryl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide → N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide (198703-58-1)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; Yield given;

DOI:10.1080/07328319708006242

Reference yield:

N2-isobutyryl-2′-O-methylguanosine (63264-29-9) → N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide (198703-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 18 h / 0 - 20 °C

2: DMAP / CH₂Cl₂ / 18 h / 0 - 20 °C

3: 1,1'-azobis(cyclohexanecarbonitrile) / chlorobenzene / 80 - 100 °C

4: OsO₄, NaIO₄ / H₂O; dioxane

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; 1,1'-azobis(1-cyanocyclohexanenitrile); In 1,4-dioxane; dichloromethane; water; chlorobenzene;

DOI:10.1080/07328319708006242

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide (198703-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 18 h / 0 - 20 °C

2: DMAP / CH₂Cl₂ / 18 h / 0 - 20 °C

3: 1,1'-azobis(cyclohexanecarbonitrile) / chlorobenzene / 80 - 100 °C

4: OsO₄, NaIO₄ / H₂O; dioxane

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; 1,1'-azobis(1-cyanocyclohexanenitrile); In 1,4-dioxane; dichloromethane; water; chlorobenzene;

DOI:10.1080/07328319708006242

upstream raw materials:

N²-isobutyryl-2′-O-methylguanosine

4,4'-dimethoxytrityl chloride

N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Thiocarbonic acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl] ester O-(3-tert-butyl-phenyl) ester

Downstream raw materials:

3'-de(oxyphosphinico)-3'-[methylene(methylimino)]-5'-O-(4,4'-dimethoxytriphenylmethyl)-2-N-isobutyryl-2'-O-methylguanosylyl-(3'->5')-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5-methyluridine

C₆₉H₈₁N₁₁O₁₃Si

C₇₂H₈₁N₉O₁₃Si

C₄₉H₅₈N₈O₁₃