Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

Base Information

Chemical Name:Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester
CAS No.:200335-35-9
Molecular Formula:C₃₂H₄₉N₄O₁₀PSi
Molecular Weight:708.821
Hs Code.:

Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

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Suppliers and Price of Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

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Chemical Property of Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

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Technology Process of Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

There total 8 articles about Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187342-10-5
5-deoxy-5-isopropylamino-1,2-O-isopropylidene-α-D-xylofuranose

: 200335-35-9
Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / NaH, NaI / tetrahydrofuran / 1.) 0 deg C, 6 h, 2.) room temperature, overnight

2: 85 percent / KHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

3: 53 percent / I₂ / methanol / 4 h / Heating

4: 1.) Py, 0 deg C, 1 h, 2.) 0 deg C, 1 h; room temperature, 12 h

5: 80 percent / H₂ / Pd/C / ethanol; acetic acid; H₂O / 36 h / 3102.9 Torr

6: PCl₃, Et₃N / CHCl₃ / 4 h / Heating

7: Et₃N / CHCl₃ / 24 h / Heating

With hydrogen; iodine; sodium hydride; potassium hydrogencarbonate; triethylamine; sodium iodide; phosphorus trichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water; acetic acid;
DOI:10.1016/S0040-4020(97)10173-9

Reference yield:

: 200335-29-1
3-O-benzyl-5-deoxy-5-isopropylamino-1,2-O-isopropylidenexylofuranose

: 200335-35-9
Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / KHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

2: 53 percent / I₂ / methanol / 4 h / Heating

3: 1.) Py, 0 deg C, 1 h, 2.) 0 deg C, 1 h; room temperature, 12 h

4: 80 percent / H₂ / Pd/C / ethanol; acetic acid; H₂O / 36 h / 3102.9 Torr

5: PCl₃, Et₃N / CHCl₃ / 4 h / Heating

6: Et₃N / CHCl₃ / 24 h / Heating

With hydrogen; iodine; potassium hydrogencarbonate; triethylamine; phosphorus trichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water; acetic acid;
DOI:10.1016/S0040-4020(97)10173-9

Reference yield:

: 200335-30-4
((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl)-isopropyl-carbamic acid benzyl ester

: 200335-35-9
Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / I₂ / methanol / 4 h / Heating

2: 1.) Py, 0 deg C, 1 h, 2.) 0 deg C, 1 h; room temperature, 12 h

3: 80 percent / H₂ / Pd/C / ethanol; acetic acid; H₂O / 36 h / 3102.9 Torr

4: PCl₃, Et₃N / CHCl₃ / 4 h / Heating

5: Et₃N / CHCl₃ / 24 h / Heating

With hydrogen; iodine; triethylamine; phosphorus trichloride; palladium on activated charcoal; In methanol; ethanol; chloroform; water; acetic acid;
DOI:10.1016/S0040-4020(97)10173-9