2-[2-Amino(methyl)anilino]-1-ethanol

Base Information

• Chemical Name: 2-[2-Amino(methyl)anilino]-1-ethanol
• CAS No.: 103763-87-7
• Molecular Formula: C9H14N2O
• Molecular Weight: 166.22000
• Hs Code.: 2922199090
• Mol file: 103763-87-7.mol

Synonyms:2-(2-aminoethylthiomethyl)-4-methoxypyridine;2-(2-amino-N-methylamino)ethanol;Ethanamine,2-[[(4-methoxy-2-pyridinyl)methyl]thio];

Chemical Property of 2-[2-Amino(methyl)anilino]-1-ethanol

Chemical Property:

• PSA: 49.49000
• LogP: 1.27850

Purity/Quality:

97% ^*data from raw suppliers

2-[(2-Aminophenyl)(methyl)amino]ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-[(2-Aminophenyl)(methyl)amino]ethanol is used as a reactant in the preparation of substituted tetrahydroquinoxalines and tetrahydrobenzo[b][1,4]diazepines by pentamethylcyclopentadienyl iridium-catalyzed hydrogen transfer N-heterocyclization of anilino alcohols.

Technology Process of 2-[2-Amino(methyl)anilino]-1-ethanol

There total 2 articles about 2-[2-Amino(methyl)anilino]-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(N-methyl-2-nitranilino)ethanol (106744-74-5) → 2-(2-amino-N-methylamino)ethanol (103763-87-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1016/S0040-4020(01)96603-7

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2-(2-amino-N-methylamino)ethanol (103763-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: H₂ / Pd/C

With hydrogen; potassium carbonate; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.07.033

Reference yield: 65.0%

phenyl isothiocyanate (103-72-0) + 2-(2-amino-N-methylamino)ethanol (103763-87-7) → 1-{2-[(2-Hydroxy-ethyl)-methyl-amino]-phenyl}-3-phenyl-thiourea (103749-13-9)

Guidance literature:

In chloroform; Ambient temperature;

DOI:10.1016/S0040-4020(01)96603-7

upstream raw materials:

2-(N-methyl-2-nitranilino)ethanol

ortho-nitrofluorobenzene

Downstream raw materials:

1-{2-[(2-Hydroxy-ethyl)-methyl-amino]-phenyl}-3-phenyl-thiourea

2-(N-methyl-2-methylaminoanilino)ethanol

1-methyl-4-phenyl(thiocarbamoyl)-1,2,3,4-tetrahydro-quinoxaline

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