2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine

Base Information

Chemical Name:2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine
CAS No.:103782-15-6
Molecular Formula:C16H16F2N2O5
Molecular Weight:354.31
Hs Code.:
DSSTox Substance ID:DTXSID401197953
Nikkaji Number:J738.771G

Synonyms:SCHEMBL9099813;VVJYJZZIXGGDDD-BFHYXJOUSA-N;DTXSID401197953;2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine;3'-O-(4-Fluorobenzyl)-5-fluoro-2'-deoxyuridine;Uridine, 2'-deoxy-5-fluoro-3'-O-[(4-fluorophenyl)methyl]-;103782-15-6

Suppliers and Price of 2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine

Chemical Property:

XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:354.10272794
Heavy Atom Count:25
Complexity:551

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)OCC3=CC=C(C=C3)F
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)OCC3=CC=C(C=C3)F

Technology Process of 2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine

There total 5 articles about 2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 103782-15-6
2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; water;

Reference yield:

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 103782-15-6
2'-deoxy-5-fluoro-3'-O-(4-fluorobenzyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / imidazole / dimethylformamide / 5.5 h / -30 °C

2: 1.) aq. KOH / 1.) toluene, dioxane, RT, 2.5 h, 2.) toluene, dioxane, RT, 6 h

3: aq. AcOH / 5 h / 40 °C

With 1H-imidazole; potassium hydroxide; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.1196