3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[[(4-methylphenyl)sulfonyl]oxy]ethyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[[(4-methylphenyl)sulfonyl]oxy]ethyl ester
• CAS No.: 103785-48-4
• Molecular Formula: C25H26N2O9S
• Molecular Weight: 530.555
• Mol file: 103785-48-4.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[[(4-methylphenyl)sulfonyl]oxy]ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[[(4-methylphenyl)sulfonyl]oxy]ethyl ester

There total 1 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[[(4-methylphenyl)sulfonyl]oxy]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxyethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (85677-95-8) + p-toluenesulfonyl chloride (98-59-9) → 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-[2-(toluene-4-sulfonyloxy)-ethyl] ester (103785-48-4)

Guidance literature:

With water; triethylamine; In tetrahydrofuran; 1.) 1 h; 2.) 0.5 h;

DOI:10.1248/cpb.34.1589

Reference yield: 77.0%

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-[2-(toluene-4-sulfonyloxy)-ethyl] ester (103785-48-4) + benzyl-methyl-amine (103-67-3) → Nicardipine (55985-32-5)

Guidance literature:

for 8h; Heating;

DOI:10.1248/cpb.34.1589

upstream raw materials:

2-hydroxyethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

p-toluenesulfonyl chloride

Downstream raw materials:

Nicardipine