Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

Base Information

Chemical Name:Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester
CAS No.:174060-75-4
Molecular Formula:C₄₆H₄₂N₇O₁₃P
Molecular Weight:931.852
Hs Code.:

Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

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Chemical Property of Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

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Technology Process of Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

There total 3 articles about Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128084-01-5,134732-11-9,138664-24-1,144731-69-1
(+/-)-7β,8α,9α-trihydroxy-10α-amino-7,8,9,10-tetrahydrobenzo pyrene

: 159950-73-9
Phosphoric acid (2R,3S,5R)-5-(6-fluoro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

: 174060-75-4
Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

: 174060-76-5
Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7R,8S,9R,10R)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

Guidance literature:: With triisobutylaluminum; In N,N-dimethyl acetamide; at 60 ℃; for 120h;
DOI:10.1021/jo9510898

Reference yield:

: 159950-72-8
Phosphoric acid (2R,3S,5R)-5-(6-chloro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

: 174060-75-4
Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Me₃N, 2.) KF / 1.) glyme, room temperature, 40 min, 2.) DMF, room temperature, 30 min

2: i-Bu₃N / N,N-dimethyl-acetamide / 120 h / 60 °C

With potassium fluoride; triisobutylaluminum; trimethylamine; In N,N-dimethyl acetamide;
DOI:10.1021/jo9510898

Reference yield:

: 173911-96-1
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-chloro-purin-9-yl)-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

: 174060-75-4
Phosphoric acid (2R,3S,5R)-2-hydroxymethyl-5-[6-((7S,8R,9S,10S)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester bis-[2-(4-nitro-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / aq. AcOH / 3 h / Ambient temperature

2: 1.) Me₃N, 2.) KF / 1.) glyme, room temperature, 40 min, 2.) DMF, room temperature, 30 min

3: i-Bu₃N / N,N-dimethyl-acetamide / 120 h / 60 °C

With potassium fluoride; triisobutylaluminum; acetic acid; trimethylamine; In N,N-dimethyl acetamide;
DOI:10.1021/jo9510898