Technology Process of (6R,7R)-8-Oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2,2-dicarboxylic acid dimethyl ester
There total 13 articles about (6R,7R)-8-Oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2,2-dicarboxylic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
Heating;
DOI:10.1139/v01-100
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 50 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C
2.1: 94 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C
3.1: ozone / CH2Cl2; methanol / -78 °C
3.2: 100 percent / dimethyl sulfide / CH2Cl2; methanol / -78 - 20 °C
4.1: 8.0 g / aqueous perchloric acid / CH2Cl2; acetone / 1.5 h
5.1: sulfuric acid / acetic acid / 2.5 h
6.1: 489 mg / p-toluenesulfonic acid monohydrate / toluene / Heating
With
perchloric acid; sulfuric acid; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; ozone;
In
methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1139/v01-100
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 78 percent / potassium permanganate; magnesium sulfate / H2O; ethanol
2.1: 50 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C
3.1: 94 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C
4.1: ozone / CH2Cl2; methanol / -78 °C
4.2: 100 percent / dimethyl sulfide / CH2Cl2; methanol / -78 - 20 °C
5.1: 8.0 g / aqueous perchloric acid / CH2Cl2; acetone / 1.5 h
6.1: sulfuric acid / acetic acid / 2.5 h
7.1: 489 mg / p-toluenesulfonic acid monohydrate / toluene / Heating
With
potassium permanganate; perchloric acid; sulfuric acid; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; toluene-4-sulfonic acid; ozone;
In
methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1139/v01-100
![(4S,6R,7R)-4-Acetoxy-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester](/Databaselist/images/loading.webp)
