diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate

Base Information

• Chemical Name: diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate
• CAS No.: 1259402-76-0
• Molecular Formula: C₉₀H₁₀₃N₁₀O₂₃PSi
• Molecular Weight: 1751.92
• Mol file: 1259402-76-0.mol

Synonyms:

Chemical Property of diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate

There total 1 articles about diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(4-methoxyphenyl)(diphenyl)methyl]-2',3'-bis-O-(4-oxopentanoyl)adenosine (1043591-15-6) + 3'-O-[(acetyloxy)methyl]-2'-O-[bis(diethylamino)phosphanyl]-5'-O-[(tert-butyl)(dimethyl)silyl]-N6-[(4-methoxyphenyl)(diphenyl)methyl]adenosine (1166394-07-5) + diethyl 2-[(acetyloxy)methyl]-2-(hydroxymethyl)propanedioate (35329-70-5) → diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate (1259402-76-0)

Guidance literature:

N-[(4-methoxyphenyl)(diphenyl)methyl]-2',3'-bis-O-(4-oxopentanoyl)adenosine; 3'-O-[(acetyloxy)methyl]-2'-O-[bis(diethylamino)phosphanyl]-5'-O-[(tert-butyl)(dimethyl)silyl]-N₆-[(4-methoxyphenyl)(diphenyl)methyl]adenosine; With 1H-tetrazole; In acetonitrile; for 0.416667h; Inert atmosphere;

diethyl 2-[(acetyloxy)methyl]-2-(hydroxymethyl)propanedioate; With 1H-tetrazole; In acetonitrile; for 1h; Inert atmosphere;

DOI:10.1002/cbdv.201000288

Reference yield:

diethyl ({[{[(2R,3R,4R,5R)-4-[(acetyloxy)methoxy]-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)tetrahydrofuran-3-yl]oxy}({(2R,3R,4R,5R)-5-(6-{[(4-methoxyphenyl)(diphenyl)methyl]amino}-9H-purin-9-yl)-3,4-bis[(4-oxopentanoyl)oxy]tetrahydrofuran-2-yl}methoxy)phosphanyl]oxy}methyl)[(acetyloxy)methyl]propanedioate (1259402-76-0) → 3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N6-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N6-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate (1259402-77-1)

Guidance literature:

With 2,6-dimethylpyridine; water; iodine; In tetrahydrofuran;

DOI:10.1002/cbdv.201000288

upstream raw materials:

N-[(4-methoxyphenyl)(diphenyl)methyl]-2',3'-bis-O-(4-oxopentanoyl)adenosine

3'-O-[(acetyloxy)methyl]-2'-O-[bis(diethylamino)phosphanyl]-5'-O-[(tert-butyl)(dimethyl)silyl]-N₆-[(4-methoxyphenyl)(diphenyl)methyl]adenosine

diethyl 2-[(acetyloxy)methyl]-2-(hydroxymethyl)propanedioate

Downstream raw materials:

3'-O-(acetyloxymethyl)-5'-O-[(tert-butyl)dimethylsilyl]-N₆-(4-methoxytrityl)adenosin-2'-yl 2',3'-di-O-levylinoyl-N₆-(4-methoxytrityl)adenosin-5'-yl 3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl phosphate