10-Oxo Thebaine

Base Information

• Chemical Name: 10-Oxo Thebaine
• CAS No.: 155051-98-2
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Mol file: 155051-98-2.mol

Synonyms:

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 10-Oxo Thebaine

Chemical Property:

• Boiling Point: 550.6±50.0 °C(Predicted)
• PKA: 5.07±0.40(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-Oxo Thebaine

There total 4 articles about 10-Oxo Thebaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

8,14-dihydro-8β-hydroxy-10-oxothebaine (155051-97-1) → 10-oxothebaine (155051-98-2)

Guidance literature:

With pyridine; trichlorophosphate; In toluene; for 3h; Heating;

Reference yield:

thebaine (115-37-7) → 10-oxothebaine (155051-98-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / NH₃, O₂, C(NO₂)4 / benzene / 2 h

2: 93 percent / aq. NaOH / ethanol / 18 h / Ambient temperature

3: 72 percent / tributyltin hydride, azoisobutyronitrile / toluene / 2 h / Heating

4: 73 percent / phosphorus oxychloride, pyridine / toluene / 3 h / Heating

With pyridine; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tetranitromethane; ammonia; oxygen; tri-n-butyl-tin hydride; trichlorophosphate; In ethanol; toluene; benzene;

Reference yield:

8α,10α-epidioxy-8,14-dihydro-14β-nitrothebaine (74260-98-3) → 10-oxothebaine (155051-98-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / aq. NaOH / ethanol / 18 h / Ambient temperature

2: 72 percent / tributyltin hydride, azoisobutyronitrile / toluene / 2 h / Heating

3: 73 percent / phosphorus oxychloride, pyridine / toluene / 3 h / Heating

With pyridine; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; trichlorophosphate; In ethanol; toluene;

upstream raw materials:

8,14-dihydro-8β-hydroxy-10-oxothebaine

thebaine

8α,10α-epidioxy-8,14-dihydro-14β-nitrothebaine

8,14-dihydro-8β-hydroxy-14β-nitro-10-oxothebaine