1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Base Information

• Chemical Name: 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
• CAS No.: 1365252-66-9
• Molecular Formula: C₂₈H₃₂FN₅O₆
• Molecular Weight: 553.59
• Mol file: 1365252-66-9.mol

Synonyms:

Chemical Property of 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

There total 7 articles about 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester (70458-93-4) → 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (1365252-66-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 80 °C

2.1: water; sodium hydroxide / 4 h / Reflux

2.2: 20 °C / pH 4

3.1: N,N-dimethyl-formamide / 24 h / 80 °C

4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; water; potassium carbonate; potassium iodide; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jm101439s

Reference yield:

1-butyl-7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (70032-24-5) → 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (1365252-66-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 24 h / 80 °C

2: 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; In N,N-dimethyl-formamide;

DOI:10.1021/jm101439s

Reference yield:

ethyl 1-butyl-7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1260740-31-5) → 1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-N-(4-methoxy-3-nitrobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (1365252-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / 4 h / Reflux

1.2: 20 °C / pH 4

2.1: N,N-dimethyl-formamide / 24 h / 80 °C

3.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; water; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jm101439s

upstream raw materials:

1-butyl-7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-butyl-7-(4-carbamoylpiperidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

ethyl 1-butyl-7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

3-nitro-4-methoxy-benzylamine