(S)-2-(2-phenyl)ethenylpyrrolidine

Base Information

• Chemical Name: (S)-2-(2-phenyl)ethenylpyrrolidine
• CAS No.: 162356-20-9
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.258
• Mol file: 162356-20-9.mol

Synonyms:

Chemical Property of (S)-2-(2-phenyl)ethenylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-phenyl)ethenylpyrrolidine

There total 6 articles about (S)-2-(2-phenyl)ethenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(tert-butoxycarbonyl)proline methyl ester (59936-29-7) → (S)-2-(2-phenyl)ethenylpyrrolidine (162356-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / DIBAH / toluene / -78 °C

2: 67 percent / KN(TMS)2 / tetrahydrofuran

3: 10percent HCl/MeOH

With hydrogenchloride; methanol; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; toluene;

DOI:10.1055/s-1997-5791

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → (S)-2-(2-phenyl)ethenylpyrrolidine (162356-20-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃ / dimethylformamide

2: 91 percent / DIBAH / toluene / -78 °C

3: 67 percent / KN(TMS)2 / tetrahydrofuran

4: 10percent HCl/MeOH

With hydrogenchloride; methanol; potassium hexamethylsilazane; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1055/s-1997-5791

Reference yield:

Boc-L-Pro-H (69610-41-9,117625-90-8) → (S)-2-(2-phenyl)ethenylpyrrolidine (162356-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / KN(TMS)2 / tetrahydrofuran

2: 10percent HCl/MeOH

With hydrogenchloride; methanol; potassium hexamethylsilazane; In tetrahydrofuran;

DOI:10.1055/s-1997-5791

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)-2-(2-phenyl)ethenylpyrrolidine

1-benzyl-1H-benzotriazole

1-(tert-butoxycarbonyl)-L-proline

(S)-N-(tert-butoxycarbonyl)proline methyl ester

Downstream raw materials:

1-[(S)-2-((E)-Styryl)-pyrrolidin-1-yl]-pent-4-en-1-one