4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid

Base Information

• Chemical Name: 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid
• CAS No.: 1423013-88-0
• Molecular Formula: C₂₆H₂₅N₃O₅
• Molecular Weight: 459.502
• Mol file: 1423013-88-0.mol

Synonyms:

Chemical Property of 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid

There total 3 articles about 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(3-formyl-1H-indol-1-yl)acetic acid tert-butyl ester (363590-49-2) + 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid (60875-16-3) → 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid (1423013-88-0)

Guidance literature:

With piperidine; In ethanol; Reflux;

DOI:10.3184/174751912X13501278349974

Reference yield:

indole (120-72-9) → 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid (1423013-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 0 - 5 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: piperidine / ethanol / Reflux

With piperidine; potassium carbonate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; 1: |Vilsmeier Reaction;

DOI:10.3184/174751912X13501278349974

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → 4-{4-[[1-(2-tert-butoxy-2-oxoethyl)-1H-indol-3-yl]methylene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid (1423013-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: piperidine / ethanol / Reflux

With piperidine; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.3184/174751912X13501278349974

upstream raw materials:

2-(3-formyl-1H-indol-1-yl)acetic acid tert-butyl ester

4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

indole

Indole-3-carboxaldehyde