H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5

Base Information Edit

Chemical Name:H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5
CAS No.:223595-70-8
Molecular Formula:C₅₂H₅₃F₅N₄O₅
Molecular Weight:909.009
Hs Code.:
Mol file:223595-70-8.mol

H-β<sup>3</sup>-hPhe-N-allyl-β<sup>3</sup>-hPhe-β<sup>3</sup>-hPhe-N-allyl-β<sup>3</sup>-hPhe-OC6F5

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5 Edit

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Technology Process of H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5

There total 10 articles about H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 312311-63-0
Boc-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5

: 223595-70-8
H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(00)00666-9

Reference yield:

: 51871-62-6
(S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid

: 223595-70-8
H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / i-Pr₂NEt; HOAt; PyBroP / CH₂Cl₂ / 16 h / 20 °C

2: 99 percent / LiOH; H₂O / dioxane / 23 h

3: 35 percent / i-Pr₂NEt; PyBroP / CH₂Cl₂ / 24 h / 20 °C

4: 78 percent / LiOH; H₂O / methanol / 20 h

5: 78 percent / EDC*HCl / CH₂Cl₂ / 15 h / 20 °C

6: TFA / CH₂Cl₂ / 3 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; 1: Acylation / 2: Hydrolysis / 3: Acylation / 4: Hydrolysis / 5: Esterification / 6: carbamate cleavage;
DOI:10.1016/S0040-4020(00)00666-9

Reference yield:

: 60398-42-7,142854-48-6
methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate

: 223595-70-8
H-β³-hPhe-N-allyl-β³-hPhe-β³-hPhe-N-allyl-β³-hPhe-OC6F5

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / LiOH; H₂O / dioxane / 20 h

2: 68 percent / i-Pr₂NEt; HOAt; PyBroP / CH₂Cl₂ / 16 h / 20 °C

3: 99 percent / LiOH; H₂O / dioxane / 23 h

4: 35 percent / i-Pr₂NEt; PyBroP / CH₂Cl₂ / 24 h / 20 °C

5: 78 percent / LiOH; H₂O / methanol / 20 h

6: 78 percent / EDC*HCl / CH₂Cl₂ / 15 h / 20 °C

7: TFA / CH₂Cl₂ / 3 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; 1: Hydrolysis / 2: Acylation / 3: Hydrolysis / 4: Acylation / 5: Hydrolysis / 6: Esterification / 7: carbamate cleavage;
DOI:10.1016/S0040-4020(00)00666-9