Ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate

Base Information

• Chemical Name: Ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate
• CAS No.: 103900-77-2
• Molecular Formula: C9H8F3NO4
• Molecular Weight: 251.15900
• Hs Code.: 2933399990
• Mol file: 103900-77-2.mol

Synonyms:ethyldihydroxytrifluoromethylnicotinate;Ethyl 4,6-Dihydroxy-2-(trifluoromethyl)-3-pyridinecarboxylate;ethyl 4,6-dihydroxy-2-(trifluoromethyl)pyridine-3-carboxylate;4,6-dihydroxy-2-trifluoromethyl-nicotinic acid ethyl ester;ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate;

Chemical Property of Ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate

Chemical Property:

• Melting Point: 217-219°
• PSA: 79.65000
• LogP: 1.68830
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4,6-Dihydroxy-2-(trifluoromethyl)nicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate

There total 2 articles about Ethyl 4,6-dihydroxy-2-(trifluoromethyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoroacetonitrile (353-85-5) + diethyl 1,3-acetonedicarboxylate (105-50-0) → Ethyl 4,6-Dihydroxy-2-(trifluoromethyl)-3-pyridinecarboxylate (103900-77-2)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction; 1) THF, below 60 deg C; or NaOAc as base;

DOI:10.1021/jo00296a077

Reference yield:

→ Ethyl 4,6-Dihydroxy-2-(trifluoromethyl)-3-pyridinecarboxylate (103900-77-2)

Guidance literature:

Reference yield: 74.0%

Ethyl 4,6-Dihydroxy-2-(trifluoromethyl)-3-pyridinecarboxylate (103900-77-2) + 4-methyl-benzaldehyde (104-87-0) → ethyl 4,6-dihydroxy-5-(4-methylbenzyl)-2-(trifluoromethyl)-nicotinate

Guidance literature:

With pyridine; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; at 100 ℃; for 4h;

DOI:10.1021/acs.joc.1c00496

upstream raw materials:

trifluoroacetonitrile

diethyl 1,3-acetonedicarboxylate

Refernces

• 1、 -. "NOVEL PHARMACEUTICALS". Page/Page column 71-72. . Retrieved 2010/11/28.