C₅₅H₇₂N₈O₁₅SSi

Base Information

• Chemical Name: C₅₅H₇₂N₈O₁₅SSi
• CAS No.: 670233-39-3
• Molecular Formula: C₅₅H₇₂N₈O₁₅SSi
• Molecular Weight: 1145.37
• Mol file: 670233-39-3.mol

Synonyms:

Chemical Property of C₅₅H₇₂N₈O₁₅SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₇₂N₈O₁₅SSi

There total 20 articles about C₅₅H₇₂N₈O₁₅SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4'S,5'R)-5,2',2',5'-Tetramethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 3'-benzyl ester (670233-34-8) → C55H72N8O15SSi (670233-39-3)

Guidance literature:

Multi-step reaction with 5 steps

1: DPPA; Et₃N / dimethylformamide

2: TFA / CHCl₃

3: aq. TBAF / tetrahydrofuran

4: 100 percent / H₂ / Pd/C / methanol

5: BOP; iPr₂NEt / dimethylformamide

With diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1246/cl.2004.72

Reference yield:

(4'S,5'R)-5,2',2',5'-Tetramethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 3'-benzyl ester 4-methyl ester (670233-33-7) → C55H72N8O15SSi (670233-39-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / LiOH / dioxane; H₂O

2: DPPA; Et₃N / dimethylformamide

3: TFA / CHCl₃

4: aq. TBAF / tetrahydrofuran

5: 100 percent / H₂ / Pd/C / methanol

6: BOP; iPr₂NEt / dimethylformamide

With lithium hydroxide; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1246/cl.2004.72

Reference yield:

(4S,5R)-4-((Z)-1-Methoxycarbonyl-propenylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid benzyl ester → C55H72N8O15SSi (670233-39-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NBS / tetrahydrofuran

1.2: Et₃N / tetrahydrofuran

2.1: Cs₂CO₃ / dioxane

3.1: 100 percent / LiOH / dioxane; H₂O

4.1: DPPA; Et₃N / dimethylformamide

5.1: TFA / CHCl₃

6.1: aq. TBAF / tetrahydrofuran

7.1: 100 percent / H₂ / Pd/C / methanol

8.1: BOP; iPr₂NEt / dimethylformamide

With lithium hydroxide; N-Bromosuccinimide; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1246/cl.2004.72

upstream raw materials:

(S)-2-{[2-((1S,2R)-1-Amino-2-hydroxy-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-hydroxy-propionic acid methyl ester

(4S,5R)-4-[(Z)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-(4-{[(4-carboxy-thiazol-2-yl)-methoxy-methyl]-carbamoyl}-5-methyl-oxazol-2-yl)-but-1-enylcarbamoyl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid

(4'S,5'R)-5,2',2',5'-Tetramethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 3'-benzyl ester