Azido-PEG5-acid

Base Information

• Chemical Name: Azido-PEG5-acid
• CAS No.: 1425973-16-5
• Molecular Formula: C₁₃H₂₅N₃O₇
• Molecular Weight: 335.357
• Mol file: 1425973-16-5.mol

Synonyms:

Chemical Property of Azido-PEG5-acid

Chemical Property:

• Solubility.: Soluble in Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

Azido-PEG5-Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG5-acid is a water soluble PEG linker. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of Azido-PEG5-acid

There total 5 articles about Azido-PEG5-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol (86770-69-6) + bromoacetic acid (79-08-3) → 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid (1425973-16-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

C17H33N3O7 (1415800-41-7) → 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid (1425973-16-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1002/cbic.202100243

Reference yield:

18-(p-toluenesulfonyloxy)-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester (850090-10-7) → 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid (1425973-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 10 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With sodium azide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cbic.202100243

upstream raw materials:

17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol

bromoacetic acid

18-(p-toluenesulfonyloxy)-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester

C₁₇H₃₃N₃O₇

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