Technology Process of C27H34FN5O3
There total 17 articles about C27H34FN5O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone tartaric acid salt;
With
triethylamine; sodium hydroxide;
In
2-methyltetrahydrofuran;
(R)-tetrahydrofuran-3-carboxylic acid chloride;
In
2-methyltetrahydrofuran; toluene;
at 20 ℃;
Cooling with ice;
DOI:10.1021/op100020z
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 2-methyltetrahydrofuran; toluene / 0 - 24 °C / Large scale reaction
2.1: pyridine; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C
3.1: sodium tris(acetoxy)borohydride / dichloromethane / 10 - 60 °C
4.1: hydrogenchloride / toluene / 25 - 35 °C
5.1: ethanol; ethyl acetate
6.1: triethylamine; sodium hydroxide / 2-methyltetrahydrofuran
6.2: 20 °C / Cooling with ice
With
pyridine; hydrogenchloride; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide;
In
2-methyltetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
2.1: Parikh-Doering oxidation;
DOI:10.1021/op100020z
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium phosphate; dipotassium hydrogenphosphate / water; acetonitrile / 2 h / 0 °C / Large scale reaction
1.2: 10 °C / Large scale reaction
2.1: palladium 10% on activated carbon; hydrogen / methabol / 60 °C / 5931.67 Torr
3.1: sodium tris(acetoxy)borohydride / dichloromethane / 10 - 60 °C
4.1: hydrogenchloride / toluene / 25 - 35 °C
5.1: ethanol; ethyl acetate
6.1: triethylamine; sodium hydroxide / 2-methyltetrahydrofuran
6.2: 20 °C / Cooling with ice
With
hydrogenchloride; potassium phosphate; dipotassium hydrogenphosphate; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide;
In
2-methyltetrahydrofuran; ethanol; dichloromethane; methabol; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/op100020z
