Technology Process of Acetic acid (3S,4S,7S,11R)-4-dibenzylamino-7-isobutyl-3-isopropyl-14-nitro-5,8-dioxo-2-oxa-6,9-diaza-bicyclo[10.2.2]hexadeca-1(15),12(16),13-trien-11-yl ester
There total 7 articles about Acetic acid (3S,4S,7S,11R)-4-dibenzylamino-7-isobutyl-3-isopropyl-14-nitro-5,8-dioxo-2-oxa-6,9-diaza-bicyclo[10.2.2]hexadeca-1(15),12(16),13-trien-11-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: SOCl2
2: NaHCO3 / dimethylsulfoxide; tetrahydrofuran / 80 °C
3: aq. K2CO3 / methanol
4: EDC / CH2Cl2
5: 75 percent / dimethylformamide / 60 °C
6: 45 percent / TBAF, 3A molecular sieves / dimethylsulfoxide / 85 °C
7: Et3N, DMAP / CH2Cl2
With
dmap; thionyl chloride; 3 A molecular sieve; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)80025-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaHCO3 / dimethylsulfoxide; tetrahydrofuran / 80 °C
2: aq. K2CO3 / methanol
3: EDC / CH2Cl2
4: 75 percent / dimethylformamide / 60 °C
5: 45 percent / TBAF, 3A molecular sieves / dimethylsulfoxide / 85 °C
6: Et3N, DMAP / CH2Cl2
With
dmap; 3 A molecular sieve; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)80025-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. K2CO3 / methanol
2: EDC / CH2Cl2
3: 75 percent / dimethylformamide / 60 °C
4: 45 percent / TBAF, 3A molecular sieves / dimethylsulfoxide / 85 °C
5: Et3N, DMAP / CH2Cl2
With
dmap; 3 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)80025-7
