N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate

Base Information

• Chemical Name: N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate
• CAS No.: 1055925-62-6
• Molecular Formula: C₂HF₃O₂*C₂₄H₂₉N₉O
• Molecular Weight: 573.578
• Mol file: 1055925-62-6.mol

Synonyms:

Chemical Property of N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate

There total 11 articles about N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide (1055925-61-5) + trifluoroacetic acid (76-05-1) → N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate (1055925-62-6)

Guidance literature:

In water; acetonitrile;

Reference yield:

1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclopentylhydrazinecarboxylate (1055926-56-1) → N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate (1055925-62-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

2.1: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C

4.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

5.1: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h

5.2: 20 °C

6.1: water; acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (20419-68-5) → N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide trifluoroacetate (1055925-62-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Heating / reflux

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

3.1: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C

5.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

6.1: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h

6.2: 20 °C

7.1: water; acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

upstream raw materials:

N'-(2-cyano-9-methyl-9H-purin-6-yl)-N'-cyclopentyl-4-(4-methyl-1-piperazinyl)benzohydrazide

trifluoroacetic acid

4-(4-methylpiperazin-4-ium-1-yl)benzoyl chloride

1,1-dimethylethyl 2-(2-cyano-9-methyl-9H-purin-6-yl)-2-cyclopentyl-hydrazine-carboxylate