4-iodo-3-methoxyphenylacetic acid

Base Information

• Chemical Name: 4-iodo-3-methoxyphenylacetic acid
• CAS No.: 1423167-37-6
• Molecular Formula: C₉H₉IO₃
• Molecular Weight: 292.073
• Mol file: 1423167-37-6.mol

Synonyms:

Chemical Property of 4-iodo-3-methoxyphenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-iodo-3-methoxyphenylacetic acid

There total 1 articles about 4-iodo-3-methoxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-iodo-3-methoxyphenylacetate (1423167-36-5) → 4-iodo-3-methoxyphenylacetic acid (1423167-37-6)

Guidance literature:

methyl 4-iodo-3-methoxyphenylacetate; With potassium hydroxide; In methanol; at 90 ℃; for 3h; Reflux; Inert atmosphere;

With hydrogenchloride; In methanol; water; Inert atmosphere;

DOI:10.1021/jm301127x

Reference yield:

4-iodo-3-methoxyphenylacetic acid (1423167-37-6) → tert-butyl 4-((2-(2-methoxybiphenyl-4-yl)acetamido)methyl)benzylcarbamate (1423167-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; sodium carbonate; tetrabutylammomium bromide / water / 120 °C / Microwave irradiation; Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; 1: |Suzuki Coupling;

DOI:10.1021/jm301127x

Reference yield:

4-iodo-3-methoxyphenylacetic acid (1423167-37-6) → C22H22N2O2 (1423167-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; sodium carbonate; tetrabutylammomium bromide / water / 120 °C / Microwave irradiation; Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; tetrabutylammomium bromide; palladium diacetate; boron tribromide; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; 1: |Suzuki Coupling;

DOI:10.1021/jm301127x

upstream raw materials:

methyl 4-iodo-3-methoxyphenylacetate

Downstream raw materials:

tert-butyl 4-((2-(2-methoxybiphenyl-4-yl)acetamido)methyl)benzylcarbamate

C₂₂H₂₂N₂O₂