(E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

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Chemical Name:(E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid
CAS No.:1430216-72-0
Molecular Formula:C₃₂H₂₆ClFN₈O₄
Molecular Weight:641.061
Hs Code.:

(E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

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Chemical Property of (E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

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Technology Process of (E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

There total 6 articles about (E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430218-08-8
tert-butyl 1-benzyl-3-methyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

: 1430216-72-0
(E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 0.75 h / 20 °C

3.1: trifluoroacetic acid / 18 h

4.1: sodium tetrahydroborate / ethanol / 1 h

5.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h

5.2: 18 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 3 h

With sodium tetrahydroborate; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: C₁₄H₁₇N₃

: 1430216-72-0
(E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 0.75 h / 20 °C

2.1: trifluoroacetic acid / 18 h

3.1: sodium tetrahydroborate / ethanol / 1 h

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h

4.2: 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 3 h

With sodium tetrahydroborate; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1430218-11-3
tert-butyl 4-(2-benzyl-3-methyl-5-(2,2,2-trifluoroacetyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoate

: 1430216-72-0
(E)-4-(1-benzyl-5-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-3-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / ethanol / 1 h

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h

2.2: 18 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h

With sodium tetrahydroborate; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; trifluoroacetic acid; In ethanol; dichloromethane;