[(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane
CAS No.:129368-43-0
Molecular Formula:C₄₀H₅₄O₆Si
Molecular Weight:658.951
Hs Code.:

[(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

Synonyms:

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Chemical Property of [(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

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Technology Process of [(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

There total 13 articles about [(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129368-42-9
(1S,2S,4S)-4-Benzyloxy-2-[(1R,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropyl]-cyclopentanol

: 107-30-2
chloromethyl methyl ether

: 129368-43-0
[(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 50 ℃;
DOI:10.1016/0040-4039(90)80020-M

Reference yield:

: 699-13-8
(tetrahydropyranyloxy)acetaldehyde

: 129368-43-0
[(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 1) LDA / 2) THF, HMPA, -78 deg C

2: Et₃N / CH₂Cl₂ / -10 °C

3: DBU / benzene / 50 °C

4: 1) Et₂O, CH₂Cl₂, 0 deg C 2) irradiation, benzophenone, -70 deg C, PhCH₃

5: 83 percent / LiAlH₄ / diethyl ether / -10 °C

6: imidazole / dimethylformamide / Ambient temperature

7: i-Pr₂NEt / 1,2-dichloro-ethane / 50 °C

With 1H-imidazole; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0040-4039(90)80020-M

Reference yield:

: 129393-13-1
(3aS,5S,6aS)-2-Ethoxy-hexahydro-cyclopenta[b]furan-5-ol

: 129368-43-0
[(1R,2R)-1-((1S,2S,4S)-4-Benzyloxy-2-methoxymethoxy-cyclopentyl)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopropylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1: NaH / tetrahydrofuran; dimethylformamide / Ambient temperature

2: 1N HCl / 1,2-dimethoxy-ethane / Ambient temperature

3: Jones reagent / acetone / 0 °C

4: 1) LDA / 2) THF, HMPA, -78 deg C

5: Et₃N / CH₂Cl₂ / -10 °C

6: DBU / benzene / 50 °C

7: 1) Et₂O, CH₂Cl₂, 0 deg C 2) irradiation, benzophenone, -70 deg C, PhCH₃

8: 83 percent / LiAlH₄ / diethyl ether / -10 °C

9: imidazole / dimethylformamide / Ambient temperature

10: i-Pr₂NEt / 1,2-dichloro-ethane / 50 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; jones reagent; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/0040-4039(90)80020-M