(S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

Base Information

Chemical Name:(S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester
CAS No.:462117-75-5
Molecular Formula:C₄₃H₅₄N₂O₁₁
Molecular Weight:774.909
Hs Code.:

(S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

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Chemical Property of (S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

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Technology Process of (S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

There total 10 articles about (S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 462117-70-0
Boc-Tyr-Ψ[CO-O]-Leu-OH

: 462117-73-3
H-Pro-Ψ[CO-O]-Thr(Bzl)-OBzl

: 462117-75-5
(S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
DOI:10.1016/S0960-894X(02)00214-7

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 462117-75-5
(S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaNO₂; H₂SO₄

2: Cs₂CO₃

3: 88 percent / DCC; DMAP

4: 97 percent / H₂ / Pd/C

5: 26 percent / BOP-Cl

With dmap; sulfuric acid; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; caesium carbonate; dicyclohexyl-carbodiimide; sodium nitrite; palladium on activated charcoal;
DOI:10.1016/S0960-894X(02)00214-7

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 462117-75-5
(S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Cs₂CO₃

2: 88 percent / DCC; DMAP

3: 97 percent / H₂ / Pd/C

4: 26 percent / BOP-Cl

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; caesium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal;
DOI:10.1016/S0960-894X(02)00214-7