4-Hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Base Information

Chemical Name:4-Hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine
CAS No.:475585-23-0
Molecular Formula:C₁₂H₇N₃O₄
Molecular Weight:257.205
Hs Code.:
DSSTox Substance ID:DTXSID601241605

Synonyms:475585-23-0;4-hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine;SCHEMBL5349637;BDALDSSHMVTBAJ-UHFFFAOYSA-N;DTXSID601241605;4-hydroxy-6-(3-nitrophenyl)furo[2.3-d]pyrimidine;6-(3-Nitrophenyl)furo[2,3-d]pyrimidin-4(3H)-one

Suppliers and Price of 4-Hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:257.04365571
Heavy Atom Count:19
Complexity:420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)[N+](=O)[O-])C2=CC3=C(O2)N=CNC3=O

Technology Process of 4-Hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

There total 4 articles about 4-Hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 475585-24-1
4-hydroxy-6-(3-nitrophenyl)furo[2,3-d]pyrimidine-5-carboxylic acid

: 475585-23-0
6-(3-nitrophenyl)furo[2,3-d]pyrimidin-4-ol

Guidance literature:: copper(I) oxide; In quinoline; at 190 ℃; for 1h;
DOI:10.1002/hlca.200490089

Reference yield:

: 52119-38-7
ethyl 3-oxo-3-(3-nitrophenyl)propanoate

: 475585-23-0
6-(3-nitrophenyl)furo[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / SO₂Cl₂ / toluene / 0.25 h / 20 °C

2.1: 61.98 g / tetrahydrofuran / 3 h / 25 °C

3.1: formic acid / dimethylformamide / 24 h / 140 °C

3.2: NaOH / H₂O / 0.5 h / 100 °C

4.1: Cu₂O / quinoline / 1 h / 190 °C

With formic acid; sulfuryl dichloride; copper(I) oxide; In tetrahydrofuran; quinoline; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.200490089

Reference yield:

: 792916-32-6
2-chloro-3-(3-nitro-phenyl)-3-oxo-propionic acid ethyl ester

: 475585-23-0
6-(3-nitrophenyl)furo[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 61.98 g / tetrahydrofuran / 3 h / 25 °C

2.1: formic acid / dimethylformamide / 24 h / 140 °C

2.2: NaOH / H₂O / 0.5 h / 100 °C

3.1: Cu₂O / quinoline / 1 h / 190 °C

With formic acid; copper(I) oxide; In tetrahydrofuran; quinoline; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200490089