(+)-6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Base Information

Chemical Name:(+)-6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
CAS No.:2080306-23-4
Molecular Formula:C₂₅H₂₃N₃O₄
Molecular Weight:429.475
Hs Code.:

Synonyms:

Suppliers and Price of (+)-6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BAY299
1mg
$ 85.00

Tocris
BAY299 ≥98%(HPLC)
5
$ 85.00

Tocris
BAY299 ≥98%(HPLC)
25
$ 318.00

DC Chemicals
BAY-299 >98%
100 mg
$ 550.00

ChemScene
BAY-299 99.24%
100mg
$ 490.00

ChemScene
BAY-299 99.24%
50mg
$ 280.00

ChemScene
BAY-299 99.24%
25mg
$ 160.00

ChemScene
BAY-299 99.24%
10mg
$ 80.00

ChemScene
BAY-299 99.24%
5mg
$ 50.00

Cayman Chemical
BAY-299 ≥98%
1mg
$ 25.00

Total 8 raw suppliers

Chemical Property of (+)-6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

BAY299 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description BAY-299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 (IC50 = 6 nM), also known as BRPF2, and the second bromodomain of transcription initiation factor TFIID subunits 1 (TAF1; IC50 = 13 nM). BAY-299 is >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 and is >300-fold selective over BRD4. See the Structural Genomics Consortium (SGC) website for more information.
Uses BAY 299, is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1, also known as BRPF2, and a strong inhibitor of TAF1/TAF1L BD2. These proteins play important roles in transcription regulation.

Technology Process of (+)-6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

There total 11 articles about (+)-6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 6-bromo-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

: 107-19-7
propargyl alcohol

: 2080306-23-4
Bay-299

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 65 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00306

Reference yield:

: 73778-94-6
5-amino-1,3,6-trimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 2080306-23-4
Bay-299

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / Inert atmosphere; Reflux

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; acetic acid; triethylamine; In tetrahydrofuran; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.7b00306

Reference yield:

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 2080306-23-4
Bay-299

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / Inert atmosphere; Reflux

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; acetic acid; triethylamine; In tetrahydrofuran; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.7b00306