Technology Process of N2-(methylsulfonyl)-N1-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide
There total 8 articles about N2-(methylsulfonyl)-N1-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C
2: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C
3: triethylamine / dichloromethane / 0.5 h / 25 °C
4: sodium azide / N,N-dimethyl acetamide / 16 h / 90 °C
5: triphenylphosphine; water / tetrahydrofuran / 1 h / 80 °C
6: 1,2-dichloro-ethane; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C
7: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
8: triethylamine / dichloromethane / 1 h
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; water; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide;
5: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2013.06.074
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C
2: triethylamine / dichloromethane / 0.5 h / 25 °C
3: sodium azide / N,N-dimethyl acetamide / 16 h / 90 °C
4: triphenylphosphine; water / tetrahydrofuran / 1 h / 80 °C
5: 1,2-dichloro-ethane; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C
6: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
7: triethylamine / dichloromethane / 1 h
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; water; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide;
4: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2013.06.074
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 0.5 h / 25 °C
2: sodium azide / N,N-dimethyl acetamide / 16 h / 90 °C
3: triphenylphosphine; water / tetrahydrofuran / 1 h / 80 °C
4: 1,2-dichloro-ethane; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C
5: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
6: triethylamine / dichloromethane / 1 h
With
hydrogenchloride; sodium azide; water; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;
3: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2013.06.074
