Technology Process of C21H27NO2
There total 5 articles about C21H27NO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C13H18O3;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at -20 ℃;
for 0.333333h;
Resolution of racemate;
(S)-1-phenyl-ethylamine;
In
dichloromethane;
at -20 - 20 ℃;
for 0.416667h;
DOI:10.1039/c1cc13650j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2.17 h / -78 - 20 °C
2.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; dimethyl sulfoxide / water; tert-butyl alcohol / 0.3 h / 0 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h / -20 °C / Resolution of racemate
3.2: 0.42 h / -20 - 20 °C
With
sodium chlorite; sodium dihydrogenphosphate dihydrate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; water; tert-butyl alcohol;
1.1: Swern oxidation;
DOI:10.1039/c1cc13650j
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; dimethyl sulfoxide / water; tert-butyl alcohol / 0.3 h / 0 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h / -20 °C / Resolution of racemate
2.2: 0.42 h / -20 - 20 °C
With
sodium chlorite; sodium dihydrogenphosphate dihydrate; oxalyl dichloride; dimethyl sulfoxide; N,N-dimethyl-formamide;
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1039/c1cc13650j
