3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline

Base Information

Chemical Name:3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline
CAS No.:3335-74-8
Molecular Formula:C₁₆H₁₄N₂O₃
Molecular Weight:282.299
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline

Chemical Property:

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Technology Process of 3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline

There total 3 articles about 3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate

: 3335-74-8
3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.75h;
DOI:10.1021/jo402099p

Reference yield:

: 1222871-98-8
(E)-tert-butyl 3-benzylidene-2-oxoindoline-1-carboxylate

: 3335-74-8
3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / dichloromethane / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.75 h

With trifluoroacetic acid; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In dichloromethane; 1: |Michael Addition;
DOI:10.1021/jo402099p

Reference yield:

: 3335-74-8
3-((S)-2-nitro-1-phenylethyl)-2-oxoindoline

Guidance literature:: 3-Benzyliden-2-oxo-2,3-dihydro-indol, Nitromethan, methanol. Natriummethylat, kurz. Erwaermen auf Siedetemp.;
DOI:10.1021/jm00329a016