(-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine

Base Information

Chemical Name:(-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine
CAS No.:72362-29-9
Molecular Formula:C₁₄H₁₉NOSe
Molecular Weight:296.271
Hs Code.:

Synonyms:

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Chemical Property of (-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine

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Technology Process of (-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine

There total 7 articles about (-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73353-98-7
(-)-(2S,4R)-N-formyl-4-formyloxyproline

: 72362-29-9
(-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / acetic anhydride / 10 h / 140 °C

2: 100 percent / conc. ethanolic ammonia / 16 h / Ambient temperature

3: 80 percent / hydrogen / 10percent Pd-C / acetic acid / 48 h / 15960 Torr / Ambient temperature

4: 90 percent / thionyl chloride / 5 h / Heating

5: 90 percent / hydrogen / Raney nickel / ethanol / 11400 Torr / Ambient temperature

6: 62 percent / i-Pr₂NH, n-BuLi

7: 61 percent / LiAlH₄

With lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; ammonia; hydrogen; diisopropylamine; palladium on activated charcoal; nickel; In ethanol; acetic anhydride; acetic acid;
DOI:10.1039/P19810000909

Reference yield:

: 73354-01-5
ethyl (+)-2-(R)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-7-carboxylate

: 72362-29-9
(-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / hydrogen / 10percent Pd-C / acetic acid / 48 h / 15960 Torr / Ambient temperature

2: 90 percent / thionyl chloride / 5 h / Heating

3: 90 percent / hydrogen / Raney nickel / ethanol / 11400 Torr / Ambient temperature

4: 62 percent / i-Pr₂NH, n-BuLi

5: 61 percent / LiAlH₄

With lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; hydrogen; diisopropylamine; palladium on activated charcoal; nickel; In ethanol; acetic acid;
DOI:10.1039/P19810000909

Reference yield:

: 73354-03-7
ethyl (+)-6α-hydroxy-8β-pyrrolizidine-1α-carboxylate

: 72362-29-9
(-)-1-hydroxymethyl-1-phenylseleno-8β-pyrrolizidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / thionyl chloride / 5 h / Heating

2: 90 percent / hydrogen / Raney nickel / ethanol / 11400 Torr / Ambient temperature

3: 62 percent / i-Pr₂NH, n-BuLi

4: 61 percent / LiAlH₄

With lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; hydrogen; diisopropylamine; nickel; In ethanol;
DOI:10.1039/P19810000909