C₁₉H₁₈N₂O₅

Base Information

• Chemical Name: C₁₉H₁₈N₂O₅
• CAS No.: 1036388-78-9
• Molecular Formula: C₁₉H₁₈N₂O₅
• Molecular Weight: 354.362
• Mol file: 1036388-78-9.mol

Synonyms:

Chemical Property of C₁₉H₁₈N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₈N₂O₅

There total 6 articles about C₁₉H₁₈N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

→ C19H18N2O5 (1036388-78-9)

Guidance literature:

Reference yield:

5-nitro-o-toluic acid (1975-52-6) → C19H18N2O5 (1036388-78-9)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 80 °C / Inert atmosphere

2: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: neat (no solvent) / 115 °C / Inert atmosphere

4: ammonia / ethylene glycol / 150 °C / Microwave irradiation

5: hydrogen; palladium 10% on activated carbon / water; tetrahydrofuran / 0.83 h

6: N,N-dimethyl-formamide; acetonitrile; water / Microwave irradiation; Heating

With thionyl chloride; palladium 10% on activated carbon; ammonia; hydrogen; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acsmedchemlett.6b00282

Reference yield:

2-methyl-5-nitrobenzoyl chloride (64688-68-2) → C19H18N2O5 (1036388-78-9)

Guidance literature:

Multi-step reaction with 5 steps

1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: neat (no solvent) / 115 °C / Inert atmosphere

3: ammonia / ethylene glycol / 150 °C / Microwave irradiation

4: hydrogen; palladium 10% on activated carbon / water; tetrahydrofuran / 0.83 h

5: N,N-dimethyl-formamide; acetonitrile; water / Microwave irradiation; Heating

With palladium 10% on activated carbon; ammonia; hydrogen; In tetrahydrofuran; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acsmedchemlett.6b00282

upstream raw materials:

5-nitro-o-toluic acid

methyl 2-methyl-5-nitrobenzoate

2-methyl-5-nitrobenzoyl chloride

(E)-methyl 2-(2-(dimethylamino)vinyl)-5-nitrobenzoate