2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%

Base Information

Chemical Name:2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%
CAS No.:1408074-44-1
Molecular Formula:C₁₁H₂₀N₂O₃
Molecular Weight:228.291
Hs Code.:2922390090
Mol file:1408074-44-1.mol

Synonyms:

Suppliers and Price of 2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tert-Butyl8-Amino-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate
5mg
$ 90.00

Synthonix
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95+%
1g
$ 1570.00

Sigma-Aldrich
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%
100mg
$ 506.00

Matrix Scientific
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95+%
1g
$ 8316.00

Crysdot
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95+%
5g
$ 4286.00

Crysdot
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95+%
1g
$ 1429.00

Chemenu
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%
1g
$ 1346.00

American Custom Chemicals Corporation
2-BOC-8-AMINO-5-OXA-2-AZASPIRO[3.4]OCTANE 95.00%
5MG
$ 498.15

AK Scientific
2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane
100mg
$ 689.00

Total 5 raw suppliers

Chemical Property of 2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%

Chemical Property:

Boiling Point:331.2±42.0 °C(Predicted)
PKA:8.07±0.20(Predicted)
Density:1.17±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tert-Butyl8-Amino-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Spirocyclic building block was first synthesized by Carreira and coworkers, which provides a new area of chemical space with straightforward functional handles for further diversification.

Technology Process of 2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95%

There total 4 articles about 2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1453315-97-3
C₁₁H₁₇NO₄

: 1408074-44-1
C₁₁H₂₀N₂O₃

Guidance literature:: C₁₁H₁₇NO₄; With titanium(IV) isopropylate; ammonia; In methanol; at 20 ℃; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol402127b

Reference yield:

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 1408074-44-1
C₁₁H₂₀N₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: potassium tert-butylate; perhydrodibenzo-18-crown-6 / tert-butyl alcohol / 9 h / Inert atmosphere; Reflux

3.1: toluene-4-sulfonic acid / acetone / 0.83 h / 0 - 20 °C / Inert atmosphere

4.1: ammonia; titanium(IV) isopropylate / methanol / 20 °C / Inert atmosphere

4.2: 3 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; perhydrodibenzo-18-crown-6; n-butyllithium; potassium tert-butylate; ammonia; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; acetone; tert-butyl alcohol;
DOI:10.1021/ol402127b

Reference yield:

: 1453315-93-9
C₁₂H₁₉NO₄

: 1408074-44-1
C₁₁H₂₀N₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; perhydrodibenzo-18-crown-6 / tert-butyl alcohol / 9 h / Inert atmosphere; Reflux

2.1: toluene-4-sulfonic acid / acetone / 0.83 h / 0 - 20 °C / Inert atmosphere

3.1: ammonia; titanium(IV) isopropylate / methanol / 20 °C / Inert atmosphere

3.2: 3 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; perhydrodibenzo-18-crown-6; potassium tert-butylate; ammonia; toluene-4-sulfonic acid; In methanol; acetone; tert-butyl alcohol;
DOI:10.1021/ol402127b