Technology Process of (1,2,3,4-tetrahydroisoquinoline-1-yl)methylamine dihydrochloride
There total 6 articles about (1,2,3,4-tetrahydroisoquinoline-1-yl)methylamine dihydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)-1H-isoindole-1,3(2H)-dione;
With
sodium tetrahydroborate; water;
In
isopropyl alcohol;
at 20 ℃;
for 8h;
With
acetic acid;
In
isopropyl alcohol;
at 80 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / dichloromethane / 2 h / 10 °C
2: N,N-dimethyl-formamide / 12 h / 90 °C
3: phosphorus pentoxide / acetonitrile / 2 h / Reflux
4: sodium tetrahydroborate; methanol / 2 h
5: sodium tetrahydroborate; acetic acid / isopropyl alcohol; water / 2 h / 80 °C
With
methanol; sodium tetrahydroborate; phosphorus pentoxide; sodium hydrogencarbonate; acetic acid;
In
dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm400944k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 12 h / 90 °C
2: phosphorus pentoxide / acetonitrile / 2 h / Reflux
3: sodium tetrahydroborate; methanol / 2 h
4: sodium tetrahydroborate; acetic acid / isopropyl alcohol; water / 2 h / 80 °C
With
methanol; sodium tetrahydroborate; phosphorus pentoxide; acetic acid;
In
water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm400944k
