C₂₅H₂₂BrClF₃N₇O₄S

Base Information

• Chemical Name: C₂₅H₂₂BrClF₃N₇O₄S
• CAS No.: 1380510-33-7
• Molecular Formula: C₂₅H₂₂BrClF₃N₇O₄S
• Molecular Weight: 688.912
• Mol file: 1380510-33-7.mol

Synonyms:

Chemical Property of C₂₅H₂₂BrClF₃N₇O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₂BrClF₃N₇O₄S

There total 6 articles about C₂₅H₂₂BrClF₃N₇O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-cyano-3-methyl-benzoic acid (871239-18-8) → C25H22BrClF3N7O4S (1380510-33-7)

Guidance literature:

Multi-step reaction with 6 steps

1: pyridine; methanesulfonyl chloride / acetonitrile

2: tetrahydrofuran

3: di-tert-butyl-diazodicarboxylate; tiolacetic acid / tetrahydrofuran / 0 °C

4: sodium hydroxide / methanol

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane

6: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane

With pyridine; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; di-tert-butyl-diazodicarboxylate; magnesium oxide; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; tiolacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2012.03.106

Reference yield:

C22H20BrClN6O3 (1380510-15-5) → C25H22BrClF3N7O4S (1380510-33-7)

Guidance literature:

Multi-step reaction with 4 steps

1: di-tert-butyl-diazodicarboxylate; tiolacetic acid / tetrahydrofuran / 0 °C

2: sodium hydroxide / methanol

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane

With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; di-tert-butyl-diazodicarboxylate; magnesium oxide; 3-chloro-benzenecarboperoxoic acid; tiolacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.106

Reference yield:

C23H22BrClN6O2S → C25H22BrClF3N7O4S (1380510-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane

With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.03.106

upstream raw materials:

2-amino-5-cyano-3-methyl-benzoic acid

2,2,2-trifluoroacetamide

2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-8-methyl-4-oxo-4H-benzo[d][1,3]oxazine-6-carbonitrile

C₂₂H₂₀BrClN₆O₃