C₁₈H₁₆F₃N₃O

Base Information

• Chemical Name: C₁₈H₁₆F₃N₃O
• CAS No.: 1469924-60-4
• Molecular Formula: C₁₈H₁₆F₃N₃O
• Molecular Weight: 347.34
• Mol file: 1469924-60-4.mol

Synonyms:

Chemical Property of C₁₈H₁₆F₃N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₆F₃N₃O

There total 3 articles about C₁₈H₁₆F₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H20F3N3O3 (1469924-47-7) → C18H16F3N3O (1469924-60-4)

Guidance literature:

With sodium hydroxide; In water; Reflux;

DOI:10.1016/j.bmcl.2013.08.012

Reference yield:

4-(5-fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid ethyl ester (107618-33-7) → C18H16F3N3O (1469924-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper dichloride; triethylamine / dichloromethane / 20 °C

2: sodium hydroxide / water / Reflux

With triethylamine; sodium hydroxide; copper dichloride; In dichloromethane; water;

DOI:10.1016/j.bmcl.2013.08.012

Reference yield:

4-(2-amino-4-fluoro-phenylamino)-piperidine-1-carboxylic acid ethyl ester (107618-21-3) → C18H16F3N3O (1469924-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 °C

2: copper dichloride; triethylamine / dichloromethane / 20 °C

3: sodium hydroxide / water / Reflux

With triethylamine; sodium hydroxide; copper dichloride; In dichloromethane; water;

DOI:10.1016/j.bmcl.2013.08.012

upstream raw materials:

C₂₁H₂₀F₃N₃O₃

4-(2-amino-4-fluoro-phenylamino)-piperidine-1-carboxylic acid ethyl ester

4-(5-fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid ethyl ester

Downstream raw materials:

C₃₀H₃₁F₃N₆O₂

C₄₀H₄₇F₃N₆O₆

Refernces