2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

Base Information

Chemical Name:2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline
CAS No.:1377503-57-5
Molecular Formula:C₁₉H₁₆N₄O
Molecular Weight:316.362
Hs Code.:

Synonyms:

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Chemical Property of 2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

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Technology Process of 2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

There total 4 articles about 2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₀N₄O₃S

: 1377503-57-5
2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

Guidance literature:: With water; potassium hydroxide; In 1,4-dioxane; at 80 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm3002982

Reference yield:

: 1377503-76-8
5-bromo-1-(phenylsulfonyl)-3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine

: 1377503-57-5
2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

3: water; potassium hydroxide / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; potassium carbonate; potassium hydroxide; In 1,4-dioxane; water; 1: Miyaura borylation / 2: Suzuki coupling;
DOI:10.1021/jm3002982

Reference yield:

: 757978-19-1
5-bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1377503-57-5
2-methoxy-5-(3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

4: water; potassium hydroxide / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; potassium carbonate; potassium hydroxide; In 1,4-dioxane; water; 1: Suzuki coupling / 2: Miyaura borylation / 3: Suzuki coupling;
DOI:10.1021/jm3002982