(3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

Base Information

Chemical Name:(3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate
CAS No.:1410737-29-9
Molecular Formula:C₂HF₃O₂*C₂₉H₃₂Cl₂FN₃O₃
Molecular Weight:674.52
Hs Code.:

(3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

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Chemical Property of (3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

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Technology Process of (3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

There total 9 articles about (3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: C₄₃H₄₄Cl₂FN₃O₄

: 76-05-1
trifluoroacetic acid

: 1410737-29-9
(3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

: C₂₉H₃₂Cl₂FN₃O₃*C₂HF₃O₂

Guidance literature:: C₄₃H₄₄Cl₂FN₃O₄; With ammonium cerium (IV) nitrate; In acetonitrile; at 20 ℃; for 0.0833333h; Inert atmosphere;

With water; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

trifluoroacetic acid; In methanol; water; Inert atmosphere;
DOI:10.1021/jm501541j

Reference yield:

: 1410737-02-8
C₂₉H₃₂Cl₂FN₃O₃

: 76-05-1
trifluoroacetic acid

: 1410737-29-9
(3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

Guidance literature:: In methanol; water;

Reference yield:

: 1410736-99-0
C₄₃H₄₄Cl₂FN₃O₄

: 76-05-1
trifluoroacetic acid

: 1410737-29-9
(3′R,4′S,5′R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-hydroxycyclohexyl)-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide trifluoroacetate

Guidance literature:: C₄₃H₄₄Cl₂FN₃O₄; With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 0.25h;

trifluoroacetic acid; In water; for 48h;
DOI:10.1021/acs.jmedchem.6b01665