C₁₈H₁₂Br₂N₄O₃S

Base Information

• Chemical Name: C₁₈H₁₂Br₂N₄O₃S
• CAS No.: 1431711-97-5
• Molecular Formula: C₁₈H₁₂Br₂N₄O₃S
• Molecular Weight: 524.192
• Mol file: 1431711-97-5.mol

Synonyms:

Chemical Property of C₁₈H₁₂Br₂N₄O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₂Br₂N₄O₃S

There total 5 articles about C₁₈H₁₂Br₂N₄O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H13Br2NO4S → C18H12Br2N4O3S (1426243-38-0) + C18H12Br2N4O3S (1431711-97-5)

Guidance literature:

C₁₈H₁₃Br₂NO₄S; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

With diphenyl phosphoryl azide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 3h; Overall yield = 577 mg; Inert atmosphere;

DOI:10.1039/c3cc39062d

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → C18H12Br2N4O3S (1426243-38-0) + C18H12Br2N4O3S (1431711-97-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 0.67 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

4.2: 3 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c3cc39062d

Reference yield:

(Z)-tert-butyl 3-(5,6-dibromo-1-tosyl-1H-indol-3-yl)acrylate → C18H12Br2N4O3S (1426243-38-0) + C18H12Br2N4O3S (1431711-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c3cc39062d

upstream raw materials:

5,6-dibromo-1H-indole-3-carboxaldehyde

5,6-dibromo-1-tosyl-1H-indole-3-carbaldehyde

p-toluenesulfonyl chloride